The Potential of Catechin-Containing Plants as Antihyperlipidemic Treatment: A Review

Authors

  • Riyadh Aqilsya Amaryl Dyas Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Islam Indonesia, Yogyakarta, Indonesia
  • Fitra Romadhonsyah Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Islam Indonesia, Yogyakarta, Indonesia https://orcid.org/0000-0001-9686-3289
  • Pinus Jumaryatno Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Islam Indonesia, Yogyakarta, Indonesia

DOI:

https://doi.org/10.29408/sinteza.v5i2.30116

Keywords:

Hyperlipidemia, Cholesterol, Triglyceride, Catechin, Medicinal Plants

Abstract

Hyperlipidemia is a condition characterized by elevated levels of cholesterol and triglycerides. Hyperlipidemia can lead to vascular disorders affecting the heart and brain, potentially resulting in severe complications such as coronary heart disease and stroke. A range of treatment strategies are employed to manage this condition encompassing the use of drugs as well as traditional medicinal approaches. Among these, the use of medicinal plants presents a promising option which considering relatively safe owing to their natural origin and minimal risk of significant side effects, as well as their bioactive compounds. Catechin is one of secondary metabolites commonly found in plants which showed various biological activities that potential for medicinal use. The aim of this review was to provide a comprehensive review of existing literature regarding the catechin-containing plants in lowering cholesterol and triglyceride levels. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was employed to select literature obtained from reputable online databases such as Google Scholar, PubMed and Science Direct which were published from 2015 to 2025. A narrative analysis was performed to assess the selected literatures. Based on literature screening, 200 articles were identified of which 14 were selected for inclusion in the review based on predefined criteria. This study highlighted the therapeutic potential of medicinal plants containing catechins which exhibit efficacy in reducing cholesterol and triglyceride levels. Medicinal plants may offer an effective herbal remedy for reducing cholesterol and triglyceride levels, with catechins may have a contribution to this activity.

References

Adelina, R. (2018). Mekanisme Katekin Sebagai Obat Antidislipidemia (Uji In Silico). Buletin Penelitian Kesehatan, 46(3), 147–154. https://doi.org/10.22435/bpk.v46i3.899

Ampangallo, E., Jafar, N., Indriasari, R., & Syam, A. (2021). Hubungan Pola Makan Dengan Kadar Kolesterol Pada Polisi Yang Mengalami Gizi Lebih Di Polresta Sidenreng Rappang. The Journal of Indonesian Community Nutrition, 10(2), 173–185.

Chen, Y., She, Y., Shi, X., Zhang, X., Wang, R., & Men, K. (2020). Green tea catechin: Does it lower blood cholesterol?, IOP Conference Series: Earth and Environmental Science, 559(1), 012027. https://doi.org/10.1088/1755-1315/559/1/012027

Deeng, D., & Mulianti, T. (2023). Pemanfaatan Tanaman Herbal Sebagai Obat Tradisional Untuk Kesehatan Masyarakat Di Desa Guaan Kecamatan Mooat Kabupaten Bolaang Mongondow Timur. HOLISTIK, Journal of Social and Culture, 16(3), 1–20.

Edo, G. I., Samuel, P. O., Oloni, G. O., Ezekiel, G. O., Onoharigho, F. O., Oghenegueke, O., Nwachukwu, S. C., Rapheal, O. A., Ajokpaoghene, M. O., Okolie, M. C., Ajakaye, R. S., Ndudi, W., & Igbodo, P. C. (2023). Review on the Biological and Bioactive components of Cocoa (Theobroma Cacao). Insight on Food, Health and Nutrition. Natural Resources for Human Health, 3(4), 426–448. https://doi.org/10.53365/nrfhh/174302

Fan, M., Kim, E.-K., Choi, Y.-J., Tang, Y., & Moon, S.-H. (2019). The Role of Momordica charantia in Resisting Obesity. International Journal of Environmental Research and Public Health, 16(18), 3251. https://doi.org/10.3390/ijerph16183251

Gabal, A. M. S. (2024). Chia (Salvia hispanica L.) Seeds: Nutritional composition and biomedical applications. Biological and Biomedical Journal, 2(1), 1–17.

Hou, D., Yousaf, L., Xue, Y., Hu, J., Wu, J., Hu, X., Feng, N., & Shen, Q. (2019). Mung Bean (Vigna radiata L.): Bioactive Polyphenols, Polysaccharides, Peptides, and Health Benefits. Nutrients, 11(6), 1238. https://doi.org/10.3390/nu11061238

Insanu, M., Karimah, H., Pramastya, H., & Fidrianny, I. (2021). Phytochemical Compounds and Pharmacological Activities of Vitis vinifera L.: An Updated Review. Biointerface Research in Applied Chemistry, 11(6), 13829–13849. https://doi.org/10.33263/BRIAC115.1382913849

Jia, X., Li, P., Wan, J., & He, C. (2017). A review on phytochemical and pharmacological properties of Litsea coreana. Pharmaceutical Biology, 55(1), 1368–1374. https://doi.org/10.1080/13880209.2017.1302482

Kumar, M., Tomar, M., Amarowicz, R., Saurabh, V., Nair, M. S., Maheshwari, C., Sasi, M., Prajapati, U., Hasan, M., Singh, S., Changan, S., Prajapat, R. K., Berwal, M. K., & Satankar, V. (2021). Guava (Psidium guajava L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Bioactivities. Foods, 10(4), 752. https://doi.org/10.3390/foods10040752

Lee, Y. L., & Lee, S. Y. (2022). Potential lipid-lowering effects of Ulmus macrocarpa Hance extract in adults with untreated high low-density lipoprotein cholesterol concentrations: A randomized double-blind placebo-controlled trial. Frontiers in medicine, 9, 1000428. https://doi.org/10.3389/fmed.2022.1000428

Mita, S. R., Husni, P., Putriana, N. A., Maharani, R., Hendrawan, R. P., & Dewi, D. A. (2024). A Recent Update on the Potential Use of Catechins in Cosmeceuticals. Cosmetics, 11(1), 23. https://doi.org/10.3390/cosmetics11010023

Naseer, Bazila & Qadri, Tahiya & Fatima, Tabasum & Bhat, Tashooq. (2021). Apples (Pyrus Malus)—Morphology, Taxonomy, Composition and Health Benefits. 10.1007/978-3-030-75502-7_2.

Rivas-Gastelum, M. F., Garcia-Amezquita, L. E., Garcia-Varela, R., & Sánchez-López, A. L. (2023). Manilkara zapota “chicozapote” as a fruit source of health-beneficial bioactive compounds and its effects on chronic degenerative and infectious diseases, a review. Frontiers in Nutrition, 10, 1194283. https://doi.org/10.3389/fnut.2023.1194283

Samanta, S. (2022). Potential Bioactive Components and Health Promotional Benefits of Tea (Camellia sinensis). Journal of the American Nutrition Association, 41(1), 65–93. https://doi.org/10.1080/07315724.2020.1827082

Samavat, H., Newman, A. R., Wang, R., Yuan, J.-M., Wu, A. H., & Kurzer, M. S. (2016). Effects of green tea catechin extract on serum lipids in postmenopausal women: A randomized, placebo-controlled clinical trial. The American Journal of Clinical Nutrition, 104(6), 1671–1682. https://doi.org/10.3945/ajcn.116.137075

Setiyawati, M., Hidayah K, N. A., & Riky, R. (2021). Gambaran Kadar Trigliserida Pada Supir Bus Di Pangkalan Bun. Jurnal Borneo Cendekia, 5(1), 118–124. https://doi.org/10.54411/jbc.v5i1.231

Thompson, P. D., Panza, G., Zaleski, A., & Taylor, B. (2016). Statin-Associated Side Effects. Journal of the American College of Cardiology, 67(20), 2395–2410. https://doi.org/10.1016/j.jacc.2016.02.071

Yazdanpanah, Z., Salehi-Abargouei, A., Mozaffari, Z., & Hemayati, R. (2023). The effect of green tea (Camellia sinensis) on lipid profiles and renal function in people with type 2 diabetes and nephropathy: a randomized controlled clinical trial. Frontiers in Nutrition, 10. https://doi.org/10.3389/fnut.2023.1253275

Yunarto, N., Elya, B., & Konadi, L. (2015). Potensi Fraksi Etil Asetat Ekstrak Daun Gambir (Uncaria gambir Roxb.) sebagai Antihiperlipidemia. Jurnal Kefarmasian Indonesia, 5(1), 1–10. https://doi.org/10.22435/jki.v5i1.4080.1-10

Yunarto, N., Sulistyaningrum, N., Kurniatri, A. A., & Elya, B. (2021). Gambir (Uncaria gambir Roxb.) as A Potential Alternative Treatment for Hyperlipidemia. Media Penelitian Dan Pengembangan Kesehatan, 31(3), 183–192. https://doi.org/10.22435/mpk.v31i3.4472

Zeni, A. L. B., Moreira, T. D., Dalmagro, A. P., Camargo, A., Bini, L. A., Simionatto, E. L., & Scharf, D. R. (2017). Evaluation of phenolic compounds and lipid-lowering effect of Morus nigra leaves extract. Anais Da Academia Brasileira de Ciências, 89(4), 2805–2815. https://doi.org/10.1590/0001-3765201720160660

Downloads

Published

2025-08-09

How to Cite

Amaryl Dyas, R. A., Romadhonsyah, F., & Jumaryatno, P. (2025). The Potential of Catechin-Containing Plants as Antihyperlipidemic Treatment: A Review. Sinteza, 5(2), 71–81. https://doi.org/10.29408/sinteza.v5i2.30116

Issue

Vol. 5 No. 2 (2025): August

Section

Articles

License

Copyright (c) 2025 Sinteza

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in Sinteza, agree to retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License (CC-BY License). This license allows authors to use all articles, data sets, graphics, and appendices in data mining applications, search engines, web sites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.