Pengaruh Edukasi Kesehatan terhadap Penggunaan Dexamethasone dan Cyproheptadine sebagai Penambah Nafsu Makan pada Remaja
DOI:
https://doi.org/10.29408/sinteza.v6i2.34056Keywords:
health education, dexamethasone, cyproheptadine, rational drug use, drug misuseAbstract
Inappropriate use of prescription drugs for non-medical purposes remains a public health concern among adolescents, particularly the use of dexamethasone and cyproheptadine as appetite stimulants. These drugs pose potential health risks when used without proper medical supervision. This study aimed to evaluate the effect of health education on adolescents’ knowledge and attitudes regarding the use of dexamethasone and cyproheptadine as appetite enhancers. A quantitative quasi-experimental study with a one-group pretest–posttest design was conducted among 30 adolescents aged 14–19 years in Aikmel Village, East Lombok, Indonesia, who had previously used or were currently using these drugs for appetite stimulation. Health education was delivered through lectures supported by leaflets containing information on drug indications, side effects, and rational use. Knowledge and attitude were measured using validated and reliable questionnaires before and after the intervention. Data were analyzed using the Wilcoxon signed-rank test. The results showed a significant increase in knowledge scores from a median of 2 (range 2–5) at pretest to 9 (range 7–10) at posttest (p < 0.001). Attitude scores also significantly improved from a median of 23 (range 20–25) to 39 (range 37–40) after the intervention (p < 0.001). These findings indicate that health education using lectures and leaflets effectively improves adolescents’ understanding and attitudes toward rational drug use. In conclusion, structured health education significantly enhances knowledge and promotes more appropriate attitudes regarding the use of dexamethasone and cyproheptadine, suggesting its potential as a preventive strategy to reduce irrational drug use among adolescents.
References
Ahmed, A. I., Aldewachi, H. S., & Aladul, M. I. (2024). Detection and Quantification of Cyproheptadine and Dexamethasone as Adulterants in Herbal Medicines and Dietary Supplements Marketed for Weight Gain. Bulletin of Pharmaceutical Sciences Assiut University, 47(2), 1093–1103. https://doi.org/10.21608/bfsa.2024.269836.2029
Amirulah, F., Yulianti, Y., & Yanti, S. I. (2024). Gambaran Tingkat Pengetahuan dan Perilaku Responden pada Penggunaan Sunscreen di Klinik Kecantikan Wilayah Bekasi. Sinteza, 4(1), 1–7. https://doi.org/10.29408/sinteza.v4i1.7926
Dahlan, M. S. (2020). Statistik untuk Kedokteran dan Kesehatan: Deskriptif, Bivariat, dan Multivariat dilengkapi Aplikasi Menggunakan SPSS (6th ed.). Epidemiologi Indonesia.
Etikan, I. (2016). Comparison of Convenience Sampling and Purposive Sampling. American Journal of Theoretical and Applied Statistics, 5(1), 1–4. https://doi.org/10.11648/j.ajtas.20160501.11
Ferilda, S., Ningsih, W., Fendri, S. T. J., Putra, R. D., & Fitriyasti, B. (2024). Rasionalitas Penggunaan Kortikosteroid pada Pasien Asma Di Rawat Inap Rumah Sakit Islam Siti Rahmah Padang. Jurnal Kesehatan Saintika Meditory, 7(1), 425–431. https://doi.org/10.30633/jsm.v7i1.2578
Ghasemi, A., & Zahediasl, S. (2012). Normality Tests for Statistical Analysis: A Guide for Non-Statisticians. International Journal of Endocrinology and Metabolism, 10(2), 486–489. https://doi.org/10.5812/ijem.3505
Gupta, M., Gupta, N., & Madabushi, J. (2023). Off-Label Cyproheptadine in Children and Adolescents: Psychiatric Comorbidities, Interacting Variables, Safety, and Risks of Hepatotoxicity. Cureus. https://doi.org/10.7759/cureus.33745
Hariadi, P., Ewisa Oktresia, E., Sovia, F., & Gemantari, B. M. (2025). Peningkatan Pengetahuan Masyarakat Melalui Edukasi: Patuhi, Obati Dan Kendalikan Diabetes. JABB, 6(1), 2025. https://doi.org/10.46306/jabb.v6i1
Khaliq, S. A., Naz, S., Farid, F., & Fatima, A. (2025). Clinical Indications and Abuse of Corticosteroids: A Narrative Review. Liaquat National Journal of Primary Care, 7(1), 59–64. https://doi.org/10.37184/lnjpc.2707-3521.7.1
Kim, S. Y., Yun, J. M., Lee, J.-W., Cho, Y. G., Cho, K.-H., Park, Y. G., & Cho, B. (2021). Efficacy and Tolerability of Cyproheptadine in Poor Appetite: A Multicenter, Randomized, Double-blind, Placebo-controlled Study. Clinical Therapeutics, 43(10), 1757–1772. https://doi.org/10.1016/j.clinthera.2021.08.001
Kim, T. K. (2015). T test as a parametric statistic. Korean Journal of Anesthesiology, 68(6), 540–546. https://doi.org/10.4097/kjae.2015.68.6.540
Nwadimkpa, O. J., Okpako, J. E. F. O., & Asogwa, E. U. (2025). Effect of Health Education on Attitude towards Illicit Drug Use among Secondary School Students in Diobu, Rivers State. Journal of Advances in Education and Philosophy, 9(02), 49–55. https://doi.org/10.36348/jaep.2025.v09i02.001
Qutob, R. A., Alhusaini, B. A., Aljarba, N. K., Alzaid, O. N., Aljahili, N. A., Alzahrani, K. S., Sharaf, M. M., Alghamdi, A. H., Alaryni, A. A., Alammari, Y. M., Alanazi, A. M., Faqihi, F. A., Al Harbi, K. M., Alsolamy, E. N., & Hakami, O. A. (2023). Public Awareness Regarding Corticosteroid Use and Side Effects: A Cross-Sectional Study in Riyadh, Saudi Arabia. Healthcare (Switzerland), 11(20). https://doi.org/10.3390/healthcare11202747
Rozi Saputro, F., Cendekia Muslimah, A., Vani Kurniawati, N., Hanin Fakhira, A., Nur Kholisah, S., Hartanti, F., Farah Fahreza, A., Yasmin Putri, S., Aulia Rahmah, R., Virza Novirianingtyas, T., Firda Salsabila, A., Solikhah, A., Balqish, N., Violita Mulyanto, A., Muhyidin, I., & Priyandani, Y. (2023). Profil Pengetahuan tentang Obat Dexamethasone sebagai Terapi Pengobatan Pasien COVID-19 pada Masyarakat di Jawa Timur. Jurnal Farmasi Komunitas, 10(1), 73–78. https://doi.org/10.20473/jfk.v10i1.41922
Sari, N. Y., Wahyuni, S., Cleodora, C., Azhar, N. O., Ramadhan, I. A., Mardinah, S., Minarni, S., Uyuni, W., Saputri, L. I., Zahratun Nisa, K., Gukguk, C. R., Waldain, B., Siahaan, A. O. M., Erikawati, F., & Amin, I. (2025). Health Education as a Means of Preventing Risky Behavior in Adolescents. Jurnal Pengabdian Masyarakat Jurusan Keperawatan, 3(2), 138–148. https://doi.org/10.22437/jpmjk.v3i2.49717
Sovia, F. (2025). Efektivitas Edukasi Tatap Muka terhadap Pengetahuan dan Sikap Swamedikasi Sediaan Sirup pada Masyarakat. Jurnal Ilmu Kesehatan Bhakti Setya Medika, 10(2). https://doi.org/10.56727/bsm.v10i2.151
Sovia, F., Anjani, R. P., & Ramadhan, L. (2024). Determinasi Kepatuhan Minum Obat pada Pasien Diabetes Mellitus Tipe II di Puskesmas Terara: Analisis Korelasi Faktor-Faktor Pengaruh. JIIS (Jurnal Ilmiah Ibnu Sina): Ilmu Farmasi Dan Kesehatan., 9(2), 357–370. https://doi.org/10.36387/jiis.v9i2.2115
Sovia, F., Hariyati, S., Oktresia, E. E., & Yuliana, T. P. (2023). Hubungan Tingkat Pengetahuan Terhadap Perilaku Swamedikasi Obat Kortikosteroid Oral pada Masyarakat Desa Semparu Lombok Tengah. Pharmauho: Jurnal Farmasi, 9(2), 28–35. https://doi.org/10.33772/pharmauho
Tavares, L. C. P., Caetano, L. de V. N., & Ianhez, M. (2024). Side effects of chronic systemic glucocorticoid therapy: what dermatologists should know. In Anais Brasileiros de Dermatologia (Vol. 99, Number 2, pp. 259–268). Elsevier Espana S.L.U. https://doi.org/10.1016/j.abd.2023.05.005
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Sinteza
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish in Sinteza, agree to retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License (CC-BY License). This license allows authors to use all articles, data sets, graphics, and appendices in data mining applications, search engines, web sites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
2.png)
